TargetMol

NCGC00229600

Product Code:
 
TAR-T12192
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12192-1mg1mg£171.00
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TAR-T12192-5mg5mg£322.00
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TAR-T12192-1mL1 mL * 10 mM (in DMSO)£348.00
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TAR-T12192-10mg10mg£470.00
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TAR-T12192-25mg25mg£707.00
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TAR-T12192-50mg50mg£978.00
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TAR-T12192-100mg100mg£1,291.00
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TAR-T12192-500mg500mg£2,456.00
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Further Information

Bioactivity:
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies.
CAS:
1338824-20-6
Formula:
C30H29N3O3
Molecular Weight:
479.58
Pathway:
GPCR/G Protein;
Purity:
0.9927
SMILES:
COc1ccc(cc1COc1c(C)cccc1C)C1Nc2ccccc2C(=O)N1Cc1cccnc1
Target:
TSH Receptor

References

1. Neumann S, et al. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.