TargetMol

NCT-505

Product Code:
 
TAR-T12196
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12196-1mg1mg£227.00
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TAR-T12196-5mg5mg£402.00
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TAR-T12196-1mL1 mL * 10 mM (in DMSO)£452.00
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TAR-T12196-10mg10mg£567.00
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TAR-T12196-25mg25mg£862.00
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TAR-T12196-50mg50mg£1,139.00
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Quantity:
TAR-T12196-100mg100mg£1,508.00
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This product comes from: United States.
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Further Information

Bioactivity:
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, >57 μM respectively.
CAS:
2231079-74-4
Formula:
C27H28FN5O3S
Molecular Weight:
521.61
Pathway:
Metabolism
Purity:
0.98
SMILES:
CS(=O)(=O)N1CCN(CC1)C(=O)c1cnc2ccc(F)cc2c1N1CCC(CC1)(C#N)c1ccccc1
Target:
Dehydrogenase

References

1. Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61(11):4883-4903.