TargetMol

NMS-P715

Product Code:
 
TAR-T12237
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12237-1mg1mg£128.00
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TAR-T12237-2mg2mg£149.00
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TAR-T12237-5mg5mg£195.00
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TAR-T12237-10mg10mg£269.00
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TAR-T12237-25mg25mg£461.00
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TAR-T12237-50mg50mg£646.00
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TAR-T12237-100mg100mg£863.00
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This product comes from: United States.
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Further Information

Bioactivity:
NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
CAS:
1202055-32-0
Formula:
C35H39F3N8O3
Molecular Weight:
676.745
Pathway:
Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; MAPK; Stem Cells; Metabolism
Purity:
0.9841
SMILES:
CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)NC3CCN(C)CC3)nc-21
Target:
Casein Kinase; Kinesin; MELK; MAPK

References

1. Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64. 2. Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315.