TargetMol

Peldesine

Product Code:
 
TAR-T12399
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12399-1mg1mg£164.00
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TAR-T12399-5mg5mg£303.00
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TAR-T12399-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T12399-10mg10mg£442.00
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TAR-T12399-25mg25mg£686.00
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TAR-T12399-50mg50mg£930.00
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TAR-T12399-100mg100mg£1,235.00
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TAR-T12399-500mg500mg£2,384.00
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Further Information

Bioactivity:
Peldesine is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection.
CAS:
133432-71-0
Formula:
C12H11N5O
Molecular Weight:
241.254
Pathway:
Cell Cycle/Checkpoint|Microbiology/Virology|DNA Damage/DNA Repair|Proteases/Proteasome
Purity:
0.98
SMILES:
Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1
Target:
HIV Protease|Nucleoside Antimetabolite/Analog

References

1. Wada Y, et al. BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor. Artif Organs. 1996 Aug;20(8):849-52. 2. Bantia S, et al. In vivo and in vitro pharmacologic activity of the purine nucleoside phosphorylase inhibitor BCX-34: the role of GTP and dGTP. Immunopharmacology. 1996 Oct;35(1):53-63. 3. New AIDS study suppresses T cells to stop viral growth. AIDS Alert. 1997 Jul;12(7):77-8. 4. Duvic M, et al. A phase III, randomized, double-blind, placebo-controlled study of peldesine (BCX-34) cream as topical therapy for cutaneous T-cell lymphoma. J Am Acad Dermatol. 2001 Jun;44(6):940-7.