TargetMol

Pozanicline dihydrochloride

Product Code:
 
TAR-T12525
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Pozanicline dihydrochloride is an orally bioavailable agonist of nicotinic acetylcholine receptor (nAChR) (Ki = 16.7 nM)
CAS:
161416-61-1
Formula:
C11H18Cl2N2O
Molecular Weight:
265.18
Pathway:
Neuroscience
Purity:
0.98
SMILES:
Cl.Cl.Cc1ncccc1OC[C@@H]1CCCN1
Target:
AChR

References

1. Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8. 2. Marks MJ, et al. Selectivity of ABT-089 for ?4?2 and ?6?2 nicotinic acetylcholine receptors in brain. Biochem Pharmacol. 2009 Oct 1;78(7):795-802. 3. Lin NH, et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J Med Chem. 1997 Jan 31;40(3):385-90.