TargetMol

SHIN1

Product Code:
 
TAR-T12897L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12897L-1mg1mg£128.00
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Quantity:
TAR-T12897L-1mL1 mL * 10 mM (in DMSO)£290.00
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Quantity:
TAR-T12897L-5mg5mg£321.00
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Quantity:
TAR-T12897L-10mg10mg£495.00
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Quantity:
TAR-T12897L-25mg25mg£760.00
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Quantity:
TAR-T12897L-50mg50mg£1,026.00
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Quantity:
TAR-T12897L-100mg100mg£1,340.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
CAS:
2146095-85-2
Formula:
C24H24N4O2
Molecular Weight:
400.482
Purity:
0.98
SMILES:
CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1

References

1. Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.