TargetMol

Sigma-1 receptor antagonist 2

Product Code:
 
TAR-T12911
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12911-1mg1mg£148.00
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TAR-T12911-5mg5mg£269.00
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TAR-T12911-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T12911-10mg10mg£402.00
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TAR-T12911-25mg25mg£626.00
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TAR-T12911-50mg50mg£862.00
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TAR-T12911-100mg100mg£1,139.00
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TAR-T12911-500mg500mg£2,207.00
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Further Information

Bioactivity:
Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).
CAS:
1639220-15-7
Formula:
C20H26ClN3O2
Molecular Weight:
375.9
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
COc1ccc(cc1)-c1nc(C)c(Cl)c(OCCCN2CCCCC2)n1
Target:
Sigma receptor

References

1. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.