TargetMol

Sigma-1 receptor antagonist 3

Product Code:
 
TAR-T12912
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12912-1mg1mg£149.00
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TAR-T12912-5mg5mg£269.00
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TAR-T12912-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T12912-10mg10mg£402.00
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TAR-T12912-25mg25mg£626.00
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TAR-T12912-50mg50mg£862.00
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TAR-T12912-100mg100mg£1,139.00
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TAR-T12912-500mg500mg£2,207.00
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Further Information

Bioactivity:
Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM). Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG, IC50 = 1.54 μM)
CAS:
1639220-17-9
Formula:
C19H23ClFN3O
Molecular Weight:
363.86
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis; GPCR/G Protein
Purity:
0.98
SMILES:
Cc1nc(nc(OCCCN2CCCCC2)c1Cl)-c1ccc(F)cc1
Target:
Sigma receptor; HER

References

1. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.