TargetMol

SPD304

Product Code:
 
TAR-T12985L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T12985L-5mg5mg£262.00
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TAR-T12985L-50mg50mg£815.00
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TAR-T12985L-100mg100mg£1,187.00
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This product comes from: United States.
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Further Information

Bioactivity:
SPD304 is a selective TNF-α inhibitor and blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 ?M for inhibiting in vitro TNF receptor 1 binding to TNF-α.
CAS:
869998-49-2
Formula:
C32H32F3N3O2
Molecular Weight:
547.622
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CN(CCN(C)Cc1coc2cc(C)c(C)cc2c1=O)Cc1cn(-c2cccc(c2)C(F)(F)F)c2ccccc12
Target:
TNF

References

1. Molly M. He, et al. Small-Molecule Inhibition of TNF-?. Science 11 Nov 2005. 2. Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim). 2014 Nov;347(11):798-805. 3. Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNF? through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7(1):3424. 4. Gallic acid induces necroptosis via TNF-? signaling pathway in activated hepatic stellate cells. Chang YJ, et al. PLoS One. 2015 Mar 27;10(3):e0120713.