TargetMol

TAS4464 hydrochloride

Product Code:
 
TAR-T13090
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13090-1mg1mg£169.00
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TAR-T13090-5mg5mg£282.00
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TAR-T13090-1mL1 mL * 10 mM (in DMSO)£324.00
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TAR-T13090-10mg10mg£414.00
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TAR-T13090-25mg25mg£646.00
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TAR-T13090-50mg50mg£863.00
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TAR-T13090-100mg100mg£1,171.00
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This product comes from: United States.
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Further Information

Bioactivity:
TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
CAS:
1848959-11-4
Formula:
C21H24ClFN6O6S
Molecular Weight:
542.97
Pathway:
Ubiquitination; Metabolism
Purity:
0.9818
SMILES:
Cl.CCOc1cccc(F)c1C#Cc1cn([C@@H]2O[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12
Target:
E1/E2/E3 Enzyme; NEDD8

References

1. Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.