TargetMol

CCR2 antagonist 4

Product Code:
 
TAR-T13114
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13114-1mg1mg£132.00
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TAR-T13114-5mg5mg£221.00
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TAR-T13114-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T13114-10mg10mg£294.00
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TAR-T13114-25mg25mg£447.00
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TAR-T13114-50mg50mg£614.00
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TAR-T13114-100mg100mg£828.00
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TAR-T13114-500mg500mg£1,581.00
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Further Information

Bioactivity:
CCR2 antagonist 4 is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).
CAS:
226226-39-7
Formula:
C21H21ClF3N3O2
Molecular Weight:
439.86
Pathway:
Immunology/Inflammation; Microbiology/Virology
Purity:
0.98
SMILES:
FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1
Target:
CCR

References

1. Moree WJ, et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1869-73. 2. Hall SE, et al. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Mol Pharmacol. 2009 Jun;75(6):1325-36. 3. Calin M, et al. VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes. Eur J Pharm Biopharm. 2015 Jan;89:18-29.