TargetMol

Valecobulin hydrochloride

Product Code:
 
TAR-T13278
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13278-1mg1mg£179.00
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TAR-T13278-5mg5mg£303.00
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TAR-T13278-1mL1 mL * 10 mM (in DMSO)£362.00
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TAR-T13278-10mg10mg£436.00
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TAR-T13278-25mg25mg£675.00
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TAR-T13278-50mg50mg£922.00
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Quantity:
TAR-T13278-100mg100mg£1,219.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Valecobulin hydrochloride is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.
CAS:
1240321-53-2
Formula:
C26H29ClN6O5S
Molecular Weight:
573.07
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
Cl.COc1cc(cc(OC)c1OC)C(=O)c1ccc(cc1-n1cncn1)-c1csc(NC(=O)[C@@H](N)C(C)C)n1
Target:
Microtubule Associated

References

1. Joo I, et al. Intravoxel incoherent motion diffusion-weighted MR imaging for monitoring the therapeutic efficacy of the vascular disrupting agent CKD-516 in rabbit VX2 liver tumors. Radiology. 2014 Aug;272(2):417-26. 2. Lee J, et al. Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J Med Chem. 2010 Sep 9;53(17):6337-54.