TargetMol

ZX-29

Product Code:
 
TAR-T13416
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13416-1mg1mg£148.00
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TAR-T13416-5mg5mg£269.00
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TAR-T13416-1mL1 mL * 10 mM (in DMSO)£325.00
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TAR-T13416-10mg10mg£389.00
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TAR-T13416-25mg25mg£603.00
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TAR-T13416-50mg50mg£830.00
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TAR-T13416-100mg100mg£1,099.00
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Further Information

Bioactivity:
ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.
CAS:
2254805-62-2
Formula:
C23H28ClN7O3S
Molecular Weight:
518.03
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9833
SMILES:
COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(C)CC1
Target:
ALK

References

1. Gou W, et al. ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation. Biochim Biophys Acta Mol Cell Res. 2020 Mar 26;1867(7):118712.