TargetMol

CDDO-dhTFEA

Product Code:
 
TAR-T13604
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13604-1mg1mg£122.00
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TAR-T13604-2mg2mg£145.00
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TAR-T13604-5mg5mg£195.00
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TAR-T13604-1mL1 mL * 10 mM (in DMSO)£229.00
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TAR-T13604-10mg10mg£286.00
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TAR-T13604-25mg25mg£503.00
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TAR-T13604-50mg50mg£695.00
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TAR-T13604-100mg100mg£946.00
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Quantity:
TAR-T13604-500mg500mg£1,813.00
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Further Information

Bioactivity:
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.
CAS:
1191265-33-4
Formula:
C33H45F3N2O3
Molecular Weight:
574.729
Pathway:
NF-κb; ; Immunology/Inflammation
Purity:
0.9888
SMILES:
[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)NCC(F)(F)F
Target:
NF-κB; Nrf2

References

1. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31. 2. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014 Jun;44(6):570-8.