TargetMol

GRK2-IN-1 hydrochloride (2055990-90-2 free base)

Product Code:
 
TAR-T13714L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13714L-200mg200mgEnquire
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TAR-T13714L-500mg500mgEnquire
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TAR-T13714L-1mg1mg£157.00
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TAR-T13714L-2mg2mg£214.00
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TAR-T13714L-5mg5mg£320.00
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TAR-T13714L-1mL1 mL * 10 mM (in DMSO)£339.00
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TAR-T13714L-10mg10mg£461.00
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TAR-T13714L-25mg25mg£772.00
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TAR-T13714L-50mg50mg£1,238.00
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TAR-T13714L-100mg100mg£1,662.00
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Further Information

Bioactivity:
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).
CAS:
T13714L
Formula:
C24H26ClFN4O4
Molecular Weight:
488.94
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
FC1=C(C(NCC2=NNC=C2)=O)C=C([C@H]3[C@H](COC4=CC=C(OCO5)C5=C4)CNCC3)C=C1.[H]Cl
Target:
GRK

References

1. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.