TargetMol

iRucaparib-AP6

Product Code:
 
TAR-T13737
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13737-100mg100mgEnquire
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TAR-T13737-50mg50mgEnquire
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TAR-T13737-1mg1mg£437.00
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TAR-T13737-5mg5mg£1,163.00
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TAR-T13737-10mg10mg£1,966.00
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This product comes from: United States.
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Further Information

Bioactivity:
iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.
CAS:
2410557-00-3
Formula:
C46H55FN6O11
Molecular Weight:
886.975
Purity:
0.98
SMILES:
CN(CCOCCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)Cc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23

References

1. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231.