TargetMol

Acivicin

Product Code:
 
TAR-T14114
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14114-1mg1mg£172.00
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Further Information

Bioactivity:
Acivicin (AT-125), a natural product produced by Streptomyces sviceus, is a γ glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
CAS:
42228-92-2
Formula:
C5H7ClN2O3
Molecular Weight:
178.57
Purity:
0.98
SMILES:
N[C@@H]([C@@H]1CC(Cl)=NO1)C(O)=O

References

1. Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition?Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26. 2. Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5.