TargetMol

AZ10606120 dihydrochloride

Product Code:
 
TAR-T14366
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14366-1mg1mg£119.00
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TAR-T14366-5mg5mg£189.00
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TAR-T14366-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T14366-10mg10mg£262.00
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TAR-T14366-25mg25mg£454.00
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TAR-T14366-50mg50mg£623.00
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Further Information

Bioactivity:
AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1]. AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM and it is little or no effect at other P2XR subtypes.
CAS:
607378-18-7
Formula:
C25H36Cl2N4O2
Molecular Weight:
495.49
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.9949
SMILES:
Cl.Cl.OCCNCCNc1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2n1
Target:
P2X Receptor

References

1. Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7(1):725.