TargetMol

AZD7507

Product Code:
 
TAR-T14380
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14380-1mg1mg£138.00
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TAR-T14380-5mg5mg£229.00
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TAR-T14380-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T14380-10mg10mg£303.00
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TAR-T14380-25mg25mg£502.00
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TAR-T14380-50mg50mg£693.00
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TAR-T14380-100mg100mg£938.00
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TAR-T14380-500mg500mg£1,813.00
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This product comes from: United States.
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Further Information

Bioactivity:
AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.
CAS:
1041852-85-0
Formula:
C23H27FN6O3
Molecular Weight:
454.506
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Membrane transporter/Ion channel
Purity:
0.9801
SMILES:
COc1cc2nnc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1N1CCN(CCO)CC1
Target:
CSF-1R; HER; Sodium Channel

References

1. Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. 2. Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125(3):1269-85. 3. Candido JB, et al. CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype. Cell Rep. 2018 May 1;23(5):1448-1460.