TargetMol

Motixafortide TFA(664334-36-5,Free)

Product Code:
 
TAR-T14665L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T14665L-1mg1mg£164.00
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TAR-T14665L-5mg5mg£336.00
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TAR-T14665L-10mg10mg£468.00
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TAR-T14665L-25mg25mg£706.00
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TAR-T14665L-50mg50mg£970.00
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TAR-T14665L-100mg100mg£1,267.00
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Further Information

Bioactivity:
Motixafortide is an antagonist of CXCR4 with IC50 of ?1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
CAS:
T14665L
Formula:
C99H145F4N33O21S2
Molecular Weight:
2273.54
Pathway:
Immunology/Inflammation; Autophagy; GPCR/G Protein
Purity:
1
SMILES:
FC(F)(F)C(O)=O.C1C[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2C1)CCCCN)CCCCN)CCCNC(=O)N)CC3=CC=C(C=C3)O)NC(=O)[C@H](CC4=CC5=CC=CC=C5C=C4)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C6=CC=C(C=C6)F)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N)CCCNC(=O)N)CCCNC(=N)N)CC7=CC=C(C=C7)O
Target:
CXCR

References

1. Abraham M , Klein S , Bulvik B , et al. The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression[J]. Leukemia, 2017, 31(11):2336-2346.