TargetMol

CAY10566

Product Code:
 
TAR-T14878
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14878-1mg1mg£108.00
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TAR-T14878-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T14878-5mg5mg£195.00
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TAR-T14878-10mg10mg£262.00
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TAR-T14878-25mg25mg£462.00
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TAR-T14878-50mg50mg£646.00
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TAR-T14878-100mg100mg£863.00
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Further Information

Bioactivity:
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively..
CAS:
944808-88-2
Formula:
C18H17ClFN5O2
Molecular Weight:
389.82
Pathway:
Metabolism
Purity:
0.9954
SMILES:
Cc1nnc(o1)-c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Cl
Target:
Dehydrogenase; Stearoyl-CoA Desaturase (SCD)

References

1. Masuda M, et al. Activating transcription factor 4 regulates stearate-induced vascular calcification. J Lipid Res. 2012 Aug;53(8):1543-52. 2. Liu G, et al. Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors. J Med Chem. 2007 Jun 28;50(13):3086-100. 3. Koeberle A, et al. Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol. J Biol Chem. 2012 Aug 3;287(32):27244-54. 4. Kamphorst JJ, et al. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8882-7.