TargetMol

CDK2-IN-4

Product Code:
 
TAR-T14916
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14916-1mg1mg£157.00
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TAR-T14916-5mg5mg£254.00
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Quantity:
TAR-T14916-1mL1 mL * 10 mM (in DMSO)£274.00
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TAR-T14916-10mg10mg£369.00
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TAR-T14916-25mg25mg£576.00
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TAR-T14916-50mg50mg£790.00
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Quantity:
TAR-T14916-100mg100mg£1,050.00
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This product comes from: United States.
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Further Information

Bioactivity:
CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.
CAS:
2079895-42-2
Formula:
C23H18N6O2S
Molecular Weight:
442.5
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9724
SMILES:
NS(=O)(=O)c1ccc(Nc2nc(-c3cccc(c3)-c3ccccc3)c3nc[nH]c3n2)cc1
Target:
CDK

References

1. Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.