TargetMol

Ciliobrevin D

Product Code:
 
TAR-T14965
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14965-1mg1mg£117.00
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TAR-T14965-2mg2mg£138.00
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TAR-T14965-5mg5mg£185.00
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TAR-T14965-1mL1 mL * 10 mM (in DMSO)£198.00
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TAR-T14965-10mg10mg£252.00
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TAR-T14965-25mg25mg£429.00
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TAR-T14965-50mg50mg£598.00
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TAR-T14965-100mg100mg£808.00
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Further Information

Bioactivity:
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity in vitro.
CAS:
1370554-01-0
Formula:
C17H8Cl3N3O2
Molecular Weight:
392.62
Pathway:
Stem Cells; Membrane transporter/Ion channel; GPCR/G Protein
Purity:
1
SMILES:
Clc1ccc(C(=O)C(C#N)=C2/NC(=O)c3ccc(Cl)cc3N2)c(Cl)c1
Target:
ATPase; Hedgehog/Smoothened

References

1. Firestone AJ, et al. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 2012 Mar 18;484(7392):125-9. 2. Miao Y, et al. Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement. Cell Cycle. 2017;16(21):2139-2145. 3. Wen Q, et al. Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E924-E948.