TargetMol

Cort108297

Product Code:
 
TAR-T15000
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15000-1mg1mg£335.00
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TAR-T15000-5mg5mg£711.00
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TAR-T15000-1mL1 mL * 10 mM (in DMSO)£870.00
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TAR-T15000-10mg10mg£946.00
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TAR-T15000-25mg25mg£1,396.00
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TAR-T15000-50mg50mg£1,862.00
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Quantity:
TAR-T15000-100mg100mg£2,424.00
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This product comes from: United States.
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Further Information

Bioactivity:
Cort108297 is a specific antagonist of the glucocorticoid receptor with a high affinity for GRs (Ki: 0.45 nM).
CAS:
1018679-79-2
Formula:
C26H25F4N3O3S
Molecular Weight:
535.55
Pathway:
Endocrinology/Hormones
Purity:
0.98
SMILES:
O=S(N1C[C@@]2(COCC)CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C2CC1)(C5=CC=C(C(F)(F)F)C=C5)=O
Target:
Glucocorticoid Receptor

References

1. Sindelar DK, et al. LLY-2707, a novel nonsteroidal glucocorticoid antagonist that reduces atypical antipsychotic-associated weight gain in rats. J Pharmacol Exp Ther. 2014 Jan;348(1):192-201. 2. Kach J, et al. Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth. Mol Cancer Ther. 2017 Aug;16(8):1680-1692. 3. Asagami T, et al. Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice. J Nutr Metab. 2011;2011:235389. 4. Solomon MB, et al. The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test. Horm Behav. 2014 Apr;65(4):363-71.