TargetMol

CYM50308

Product Code:
 
TAR-T15032
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15032-1mg1mg£116.00
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TAR-T15032-5mg5mg£187.00
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TAR-T15032-1mL1 mL * 10 mM (in DMSO)£197.00
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TAR-T15032-10mg10mg£244.00
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TAR-T15032-25mg25mg£364.00
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TAR-T15032-50mg50mg£511.00
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TAR-T15032-100mg100mg£683.00
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TAR-T15032-200mg200mg£870.00
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Further Information

Bioactivity:
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.
CAS:
1345858-76-5
Formula:
C20H21F2N3O2S
Molecular Weight:
405.46
Pathway:
GPCR/G Protein
Purity:
0.9943
SMILES:
COCCN=C1/SC(=C/c2cc(C)n(c2C)-c2ccc(F)cc2F)C(=O)N1C
Target:
S1P Receptor; LPL Receptor

References

1. Urbano M, et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45.