TargetMol

Danicamtiv

Product Code:
 
TAR-T15050
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15050-1mg1mg£201.00
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TAR-T15050-5mg5mg£303.00
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TAR-T15050-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T15050-10mg10mg£454.00
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TAR-T15050-25mg25mg£704.00
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TAR-T15050-50mg50mg£938.00
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Quantity:
TAR-T15050-100mg100mg£1,259.00
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This product comes from: United States.
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Further Information

Bioactivity:
Danicamtiv is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
CAS:
1970972-74-7
Formula:
C16H20F3N5O4S
Molecular Weight:
435.42
Pathway:
Cytoskeletal Signaling
Purity:
0.9975
SMILES:
Cn1cc(c(n1)C(F)F)S(=O)(=O)[C@@](C)(F)C1CCN(CC1)C(=O)Nc1ccon1
Target:
Myosin

References

1. Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707 2. Johan Oslob, et al. 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm). WO2016118774A1.