TargetMol

DK419

Product Code:
 
TAR-T15137
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15137-1mg1mg£179.00
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TAR-T15137-5mg5mg£303.00
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TAR-T15137-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T15137-10mg10mg£436.00
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TAR-T15137-25mg25mg£675.00
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TAR-T15137-50mg50mg£922.00
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Quantity:
TAR-T15137-100mg100mg£1,219.00
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This product comes from: United States.
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Further Information

Bioactivity:
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
CAS:
2102672-22-8
Formula:
C16H8ClF6N3O
Molecular Weight:
407.7
Pathway:
Cytoskeletal Signaling; Stem Cells
Purity:
0.9815
SMILES:
FC(F)(F)c1nc2cc(Cl)cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c2[nH]1
Target:
Wnt/beta-catenin

References

1. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/?-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.