TargetMol

Eleclazine hydrochloride

Product Code:
 
TAR-T15207
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15207-1mg1mg£163.00
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TAR-T15207-5mg5mg£269.00
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TAR-T15207-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T15207-10mg10mg£369.00
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TAR-T15207-25mg25mg£576.00
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TAR-T15207-50mg50mg£790.00
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TAR-T15207-100mg100mg£1,050.00
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Further Information

Bioactivity:
Eleclazine hydrochloride is a novel inhibitor of late Na+ current (IC50: 0.7 uM).
CAS:
1448754-43-5
Formula:
C21H17ClF3N3O3
Molecular Weight:
451.83
Pathway:
Membrane transporter/Ion channel
Purity:
0.9895
SMILES:
Cl.FC(F)(F)Oc1ccc(cc1)-c1ccc2OCCN(Cc3ncccn3)C(=O)c2c1
Target:
Sodium Channel

References

1. Rajamani S et al. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. Br J Pharmacol. 2016 Jul 23. 2. Justo F et al. Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation. Heart Rhythm. 2016 Sep;13(9):1860-7.