TargetMol

Fenobam

Product Code:
 
TAR-T15275
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15275-1mg1mg£109.00
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TAR-T15275-5mg5mg£148.00
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TAR-T15275-1mL1 mL * 10 mM (in DMSO)£188.00
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TAR-T15275-10mg10mg£209.00
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TAR-T15275-25mg25mg£302.00
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TAR-T15275-50mg50mg£418.00
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TAR-T15275-100mg100mg£575.00
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TAR-T15275-500mg500mg£1,107.00
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Further Information

Bioactivity:
Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively).
CAS:
57653-26-6
Formula:
C11H11ClN4O2
Molecular Weight:
266.69
Pathway:
Neuroscience
Purity:
0.9944
SMILES:
CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1
Target:
GluR

References

1. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. 2. Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.bioRxiv 391383; 3. Keck TM, et al. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl). 2013;229(2):253-265.