TargetMol

GDC-0339

Product Code:
 
TAR-T15376
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15376-5mg5mg£404.00
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TAR-T15376-50mg50mg£1,797.00
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Quantity:
TAR-T15376-100mg100mg£3,066.00
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This product comes from: United States.
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Further Information

Bioactivity:
GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of the pan-Pim kinase (Kis: 0.03 nM, 0.1 nM, and 0.02 nM for Pim1, Pim2, and Pim3, respectively).
CAS:
1428569-85-0
Formula:
C20H22F3N7OS
Molecular Weight:
465.5
Pathway:
Chromatin/Epigenetic; JAK/STAT signaling
Purity:
0.98
SMILES:
Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)[C@H](F)CC1
Target:
Pim

References

1. Takahashi RH, et al. CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339. Drug Metab Dispos. 2017 Oct;45(10):1084-1092. 2. Wang X, et al. Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. J Med Chem. 2019 Feb 28;62(4):2140-2153.