TargetMol

GN44028

Product Code:
 
TAR-T15396
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15396-1mg1mg£156.00
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TAR-T15396-5mg5mg£254.00
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TAR-T15396-1mL1 mL * 10 mM (in DMSO)£274.00
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TAR-T15396-10mg10mg£346.00
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TAR-T15396-25mg25mg£531.00
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TAR-T15396-50mg50mg£726.00
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Quantity:
TAR-T15396-100mg100mg£938.00
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Further Information

Bioactivity:
GN44028 is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization.
CAS:
1421448-26-1
Formula:
C18H15N3O2
Molecular Weight:
305.337
Pathway:
Chromatin/Epigenetic; Angiogenesis
Purity:
0.982
SMILES:
C1c2ccccc2-c2[nH]nc(Nc3ccc4OCCOc4c3)c12
Target:
HIF

References

1. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4(2):297-301.