TargetMol

GNE-781

Product Code:
 
TAR-T15405
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15405-1mg1mg£211.00
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TAR-T15405-5mg5mg£369.00
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TAR-T15405-1mL1 mL * 10 mM (in DMSO)£401.00
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TAR-T15405-10mg10mg£517.00
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TAR-T15405-25mg25mg£790.00
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TAR-T15405-50mg50mg£1,050.00
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Quantity:
TAR-T15405-100mg100mg£1,396.00
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Further Information

Bioactivity:
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).
CAS:
1936422-33-1
Formula:
C27H33F2N7O2
Molecular Weight:
525.605
Pathway:
Chromatin/Epigenetic
Purity:
0.9873
SMILES:
CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Target:
Epigenetic Reader Domain

References

1. Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Nov 22;60(22):9162-9183.