TargetMol

GSK2795039

Product Code:
 
TAR-T15433
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15433-1mg1mg£124.00
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TAR-T15433-2mg2mg£149.00
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TAR-T15433-5mg5mg£201.00
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TAR-T15433-1mL1 mL * 10 mM (in DMSO)£213.00
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TAR-T15433-10mg10mg£275.00
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TAR-T15433-25mg25mg£434.00
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TAR-T15433-50mg50mg£598.00
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TAR-T15433-100mg100mg£821.00
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Further Information

Bioactivity:
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
CAS:
1415925-18-6
Formula:
C23H26N6O2S
Molecular Weight:
450.56
Pathway:
NF-κb; Apoptosis; Metabolism; Immunology/Inflammation
Purity:
0.9868
SMILES:
CC(C)n1cc(-c2ccc3CCN(C)c3c2)c2c(NS(=O)(=O)c3ccn(C)n3)ccnc12
Target:
Apoptosis; Reactive Oxygen Species; ROS; NADPH

References

1. Hirano K, et al. Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal. 2015 Aug 10;23(5):358-74. 2. Yauger YJ, et al. Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro. J Neuroinflammation. 2019 Feb 18;16(1):41.