TargetMol

Indotecan

Product Code:
 
TAR-T15578
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15578-50mg50mgEnquire
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Quantity:
TAR-T15578-1mg1mg£122.00
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TAR-T15578-5mg5mg£173.00
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TAR-T15578-10mg10mg£249.00
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Quantity:
TAR-T15578-25mg25mg£389.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
CAS:
915303-09-2
Formula:
C26H26N2O7
Molecular Weight:
478.501
Pathway:
DNA Damage/DNA Repair
Purity:
0.97
SMILES:
COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCN3CCOCC3)c(=O)c2cc1OC
Target:
Topoisomerase

References

1. Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.