TargetMol

MKC8866

Product Code:
 
TAR-T15594
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15594-1mg1mg£135.00
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TAR-T15594-5mg5mg£229.00
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TAR-T15594-1mL1 mL * 10 mM (in DMSO)£242.00
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TAR-T15594-10mg10mg£328.00
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TAR-T15594-25mg25mg£503.00
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TAR-T15594-50mg50mg£696.00
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Quantity:
TAR-T15594-100mg100mg£946.00
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Quantity:
TAR-T15594-500mg500mg£1,821.00
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This product comes from: United States.
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Further Information

Bioactivity:
MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.
CAS:
1338934-59-0
Formula:
C18H19NO7
Molecular Weight:
361.35
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9935
SMILES:
COc1cc2c(C)c(CC(=O)N3CCOCC3)c(=O)oc2c(C=O)c1O
Target:
IRE1

References

1. Sheng X, et al. IRE1?-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nat Commun. 2019 Jan 24;10(1):323. 2. Logue SE, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018 Aug 15;9(1):3267.