TargetMol

KGA-2727

Product Code:
 
TAR-T15656
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15656-1mg1mg£179.00
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TAR-T15656-2mg2mg£226.00
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TAR-T15656-5mg5mg£303.00
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TAR-T15656-1mL1 mL * 10 mM (in DMSO)£343.00
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TAR-T15656-10mg10mg£454.00
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TAR-T15656-25mg25mg£704.00
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TAR-T15656-50mg50mg£938.00
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TAR-T15656-100mg100mg£1,259.00
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Further Information

Bioactivity:
KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 for the treatment of diabete.
CAS:
666842-36-0
Formula:
C26H40N4O8
Molecular Weight:
536.626
Pathway:
GPCR/G Protein
Purity:
0.9895
SMILES:
CC(C)c1[nH]nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(OCCCNCCC(N)=O)cc1C
Target:
SGLT

References

1. Shibazaki T, et al. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96.