TargetMol

KT5823

Product Code:
 
TAR-T15670
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15670-1mg1mg£2,641.00
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Further Information

Bioactivity:
KT5823 is a selective the cGMP-dependent protein kinase (PKG) inhibitor (Ki: 0.23 μM), it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively.
CAS:
126643-37-6
Formula:
C29H25N3O5
Molecular Weight:
495.535
Purity:
0.98
SMILES:
[H][C@]12C[C@](OC)(C(=O)OC)[C@](C)(O1)n1c3ccccc3c3c4CN(C)C(=O)c4c4c5ccccc5n2c4c13

References

1. Gadbois DM, et al. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30. 2. Wyatt TA, et al. KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin. Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):3-14. 3. Chan SL, et al. Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod. 2003 Dec;9(12):775-83.