TargetMol

MMP13-IN-3

Product Code:
 
TAR-T16124
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16124-1mg1mg£149.00
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TAR-T16124-5mg5mg£269.00
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TAR-T16124-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T16124-10mg10mg£389.00
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TAR-T16124-25mg25mg£603.00
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TAR-T16124-50mg50mg£830.00
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Quantity:
TAR-T16124-100mg100mg£1,099.00
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This product comes from: United States.
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Further Information

Bioactivity:
MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.
CAS:
1222173-37-6
Formula:
C24H22N4O5
Molecular Weight:
446.463
Pathway:
Proteases/Proteasome
Purity:
0.98
SMILES:
CCOC(=O)c1cc2cc(ccc2[nH]1)-c1cc(nn1C)C(=O)NCc1ccc(cc1)C(O)=O
Target:
MMP

References

1. Taylor SJ, et al. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54(23):8174-87. 2. Ruminski PG, et al. Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem. 2016 Jan 14;59(1):313-27.