TargetMol

MRK-560

Product Code:
 
TAR-T16133
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16133-1mg1mg£114.00
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TAR-T16133-5mg5mg£173.00
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TAR-T16133-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-T16133-10mg10mg£229.00
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TAR-T16133-25mg25mg£389.00
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TAR-T16133-50mg50mg£568.00
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TAR-T16133-100mg100mg£780.00
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Further Information

Bioactivity:
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
CAS:
677772-84-8
Formula:
C19H17ClF5NO4S2
Molecular Weight:
517.91
Pathway:
Neuroscience; Proteases/Proteasome; Stem Cells
Purity:
0.98
SMILES:
Fc1ccc(F)c(c1)[C@]1(CC[C@@H](CC1)NS(=O)(=O)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1
Target:
Gamma-secretase

References

1. Best JD, et al. The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8.