TargetMol

Naluzotan

Product Code:
 
TAR-T16265
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T16265-5mg5mg£930.00
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Quantity:
TAR-T16265-50mg50mg£1,821.00
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Quantity:
TAR-T16265-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
Naluzotan is an effective and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM. Naluzotan is used for the treatment of anxiety and depression and is also a weak hERG K+ channel blocker (IC50: 3800 nM).
CAS:
740873-06-7
Formula:
C23H38N4O3S
Molecular Weight:
450.64
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.98
SMILES:
CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1
Target:
BTK

References

1. Becker OM, et al. An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. J Med Chem. 2006 Jun 1;49(11):3116-35. 2. Brunelli SA, et al. PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety. Pharmacol Biochem Behav. 2009 Nov;94(1):8-15.