TargetMol

KL1333

Product Code:
 
TAR-T16342
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16342-1mg1mg£183.00
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TAR-T16342-2mg2mg£229.00
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TAR-T16342-1mL1 mL * 10 mM (in DMSO)£292.00
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TAR-T16342-5mg5mg£302.00
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TAR-T16342-10mg10mg£431.00
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TAR-T16342-25mg25mg£664.00
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TAR-T16342-50mg50mg£863.00
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TAR-T16342-100mg100mg£1,187.00
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Further Information

Bioactivity:
KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
CAS:
1800405-30-4
Formula:
C14H12N2O2
Molecular Weight:
240.262
Pathway:
Metabolism
Purity:
0.9927
SMILES:
CC(C)c1nc-2c([nH]1)C(=O)C(=O)c1ccccc-21
Target:
NADPH; Mitochondrial Metabolism

References

1. Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018 Jul 5;9:552.