TargetMol

NS13001

Product Code:
 
TAR-T16345
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16345-1mg1mg£111.00
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TAR-T16345-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T16345-5mg5mg£182.00
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TAR-T16345-10mg10mg£266.00
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TAR-T16345-25mg25mg£389.00
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TAR-T16345-50mg50mg£543.00
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TAR-T16345-100mg100mg£755.00
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Further Information

Bioactivity:
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
CAS:
1063331-94-1
Formula:
C17H16ClN7
Molecular Weight:
353.81
Pathway:
Membrane transporter/Ion channel
Purity:
0.9955
SMILES:
Cc1cc(C)n(n1)-c1nc(Nc2ccc(Cl)cc2)c2ncn(C)c2n1
Target:
Potassium Channel

References

1. Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.