Okadaic acid

Product Code:

TAR-T16381

Product Group:

Natural Products and Extracts

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T16381-1mg

1mg

£3,323.00

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Further Information

Bioactivity:

Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted from black sponges of the genus Halichondria. Okadaic acid eliminates metazoan symbionts/parasites by apoptosis.

CAS:

78111-17-8

Formula:

C44H68O13

Molecular Weight:

805.015

Purity:

0.98

SMILES:

[H][C@]1(CC(C)=C[C@@]2(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]2O)O1)[C@H](C)C=C[C@H]1CC[C@@]2(CC[C@@]3([H])O[C@]([H])([C@@H](O)C[C@H](C)[C@@]4([H])O[C@@]5(CCCCO5)CC[C@H]4C)C(=C)[C@@H](O)[C@]3([H])O2)O1

Documents

References

1. Bialojan C, et al. Inhibitory?effect?of a?marine-sponge?toxin,?okadaic acid, on?protein phosphatases. Specificity and kinetics. Biochem J.?1988 Nov 15;256(1):283-90. 2. McCluskey A, et al. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem.?2002 Mar 14;45(6):1151-75. 3. Schr?der HC, et al. Okadaic?acid, an?apoptogenic?toxin?for?symbiotic/parasitic?annelids?in the?demosponge?Suberites?domuncula. Appl Environ Microbiol.?2006 Jul;72(7):4907-16.