TargetMol

Pozanicline hydrochloride

Product Code:
 
TAR-T16563L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T16563L-1mg1mg£227.00
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TAR-T16563L-1mL1 mL * 10 mM (in DMSO)£375.00
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TAR-T16563L-5mg5mg£422.00
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TAR-T16563L-10mg10mg£589.00
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TAR-T16563L-25mg25mg£863.00
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TAR-T16563L-50mg50mg£1,179.00
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TAR-T16563L-100mg100mg£1,564.00
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TAR-T16563L-500mg500mg£3,058.00
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Further Information

Bioactivity:
Pozanicline hydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline hydrochloride is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2].
CAS:
0
Formula:
C11H17ClN2O
Molecular Weight:
228.72
Pathway:
Neuroscience
Purity:
0.98
SMILES:
[H]Cl.CC1=NC=CC=C1OC[C@H]2NCCC2
Target:
AChR

References

1. Lin NH, et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J Med Chem. 1997 Jan 31;40(3):385-90. 2. Marks MJ, et al. Selectivity of ABT-089 for ?4?2 and ?6?2 nicotinic acetylcholine receptors in brain. Biochem Pharmacol. 2009 Oct 1;78(7):795-802. 3. Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8.