TargetMol

PYZD-4409

Product Code:
 
TAR-T16699
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16699-1mg1mg£100.00
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TAR-T16699-5mg5mg£140.00
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TAR-T16699-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T16699-10mg10mg£187.00
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TAR-T16699-25mg25mg£283.00
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TAR-T16699-50mg50mg£430.00
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TAR-T16699-100mg100mg£590.00
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TAR-T16699-500mg500mg£1,139.00
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This product comes from: United States.
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Further Information

Bioactivity:
PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.
CAS:
423148-78-1
Formula:
C14H7ClFN3O5
Molecular Weight:
351.67
Pathway:
Ubiquitination;
Purity:
0.98
SMILES:
[O-][N+](=O)c1ccc(C=C2C(=O)NN(C2=O)c2ccc(F)c(Cl)c2)o1
Target:
E1/E2/E3 Enzyme

References

1. Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9.