TargetMol

Rhosin hydrochloride

Product Code:
 
TAR-T16745
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16745-1mg1mg£201.00
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TAR-T16745-2mg2mg£254.00
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TAR-T16745-5mg5mg£349.00
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TAR-T16745-1mL1 mL * 10 mM (in DMSO)£377.00
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TAR-T16745-10mg10mg£470.00
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TAR-T16745-25mg25mg£707.00
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TAR-T16745-50mg50mg£938.00
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TAR-T16745-100mg100mg£1,235.00
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Further Information

Bioactivity:
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride causes cell apoptosis.
CAS:
1281870-42-5
Formula:
C20H19ClN6O
Molecular Weight:
394.86
Pathway:
Apoptosis; GPCR/G Protein; Cell Cycle/Checkpoint; MAPK
Purity:
0.9892
SMILES:
Cl.N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN=Cc1ccc2nccnc2c1
Target:
Apoptosis; Rho; Ras

References

1. Shang X, et al. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem Biol. 2012 Jun 22;19(6):699-710. 2. Shang X, et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.