TargetMol

RMC-4550

Product Code:
 
TAR-T16762
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16762-1mg1mg£115.00
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TAR-T16762-5mg5mg£168.00
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TAR-T16762-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T16762-10mg10mg£230.00
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TAR-T16762-25mg25mg£436.00
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TAR-T16762-50mg50mg£610.00
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TAR-T16762-100mg100mg£838.00
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Further Information

Bioactivity:
RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
CAS:
2172651-73-7
Formula:
C21H26Cl2N4O2
Molecular Weight:
437.37
Pathway:
Metabolism
Purity:
0.9965
SMILES:
C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N
Target:
Phosphatase

References

1. Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20(9):1064-1073. 2. lena S. Koltun, Naing Aay et al. Abstract 4878: RMC-4550, an allosteric inhibitor of SHP2: Synthesis, structure, and anti-tumor activity. Experimental and Molecular Therapeutics AM2018-4878 Published July 2018