TargetMol

SHU 9119 acetate

Product Code:
 
TAR-T16879L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16879L-1mg1mg£142.00
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TAR-T16879L-5mg5mg£378.00
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TAR-T16879L-10mg10mg£532.00
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TAR-T16879L-1mL1 mL * 10 mM (in DMSO)£590.00
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TAR-T16879L-25mg25mg£812.00
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TAR-T16879L-50mg50mg£1,083.00
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Further Information

Bioactivity:
SHU 9119 acetate is a well-known antagonist of human melanocortin 3 and 4 (hMC3R, hMC4R) receptors and a partial hMC5R agonist. The IC50 values of human MC3R, MC4R and MC5R is 0.23, 0.06, and 0.09 nM respectively.
CAS:
T16879L
Formula:
C56H75N15O11
Molecular Weight:
1134.29
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
CCCC[C@@H](C(N[C@H]1CC(NCCCC[C@@H](C(N)=O)NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CC2=CNC=N2)=O)CC3=CC4=CC=CC=C4C=C3)=O)CCCNC(N)=N)=O)CC5=CNC6=C5C=CC=C6)=O)=O)=O)NC(C)=O.CC(O)=O
Target:
Melanocortin Receptor

References

1. Grieco P, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and Peptides. 2007 Jun;28(6):1191-6. 2. Nogueiras R, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest. 2007 Nov;117(11):3475-88. 3. Kooijman S, et al. Inhibition of the central melanocortin system decreases brown adipose tissue activity. J Lipid Res. 2014 Oct;55(10):2022-32.