TargetMol

SW-100

Product Code:
 
TAR-T16962
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16962-1mg1mg£111.00
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TAR-T16962-2mg2mg£130.00
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TAR-T16962-5mg5mg£168.00
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TAR-T16962-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T16962-10mg10mg£229.00
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TAR-T16962-25mg25mg£334.00
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TAR-T16962-50mg50mg£463.00
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TAR-T16962-100mg100mg£643.00
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Further Information

Bioactivity:
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier.
CAS:
2126744-35-0
Formula:
C17H17ClN2O2
Molecular Weight:
316.79
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.98
SMILES:
ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Target:
HDAC

References

1. Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.