TargetMol

ACBI1

Product Code:
 
TAR-T17350
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17350-1mg1mg£149.00
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TAR-T17350-5mg5mg£261.00
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TAR-T17350-10mg10mg£377.00
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TAR-T17350-25mg25mg£584.00
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TAR-T17350-50mg50mg£804.00
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TAR-T17350-100mg100mg£1,058.00
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Further Information

Bioactivity:
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
CAS:
2375564-55-7
Formula:
C49H58FN9O7S
Molecular Weight:
936.1
Pathway:
Apoptosis; Chromatin/Epigenetic
Purity:
0.9815
SMILES:
CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
Target:
Apoptosis; Epigenetic Reader Domain

References

1. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.